Allied Health Services

Tissue Engineering for the Heart: A Case Study Based by Ravi Birla

By Ravi Birla

This e-book covers the basics of tissue engineering for the center, beginning with the fundamentals of organ iteration, sensors in tissue and organ fabrication, and the present cutting-edge in stem mobilephone engineering for the center. With this beginning in position, the remainder chapters specialise in particular facets of the cardiovascular process, beginning with center muscle, then organic pumps, via bioartificial ventricles, and at last, bioartificial hearts. during the process this ebook, twenty-two in-depth case stories are offered. every one case learn has been chosen to demonstrate particular layout schemes for tissue and organ fabrication. this is often an incredible booklet for upper-level undergraduate and graduate scholars learning tissue engineering and organ regeneration, particularly these considering cardiac regeneration.

This ebook also:

Includes twenty-two case reports that illustrate particular layout schemes for engineering the heart

Provides open-ended dialogue questions on the finish of every bankruptcy in addition to a close reference checklist to motivate additional learn and reading

Covers the fundamentals of organ fabrication in addition to sensor know-how and genetic engineering as they relate to tissue and organ fabrication

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Tissue Engineering for the Heart: A Case Study Based Approach

This ebook covers the basics of tissue engineering for the center, beginning with the fundamentals of organ iteration, sensors in tissue and organ fabrication, and the present cutting-edge in stem mobile engineering for the center. With this origin in position, the remainder chapters specialise in particular elements of the cardiovascular method, beginning with center muscle, then organic pumps, through bioartificial ventricles, and at last, bioartificial hearts.

Extra resources for Tissue Engineering for the Heart: A Case Study Based Approach

Example text

Although the field of tissue engineering is nascent, several important milestones have been achieved in the area of stem cell engineering, biomaterial synthesis, sensors and bioreactor technology. 2 · The Organ Fabrication Pathway have been developed in the field of tissue engineering, researchers have expanded this space and applied these technologies for the fabrication of bioartificial organs. The transition has been from the fabrication of planar 3D artificial tissue to fabrication of complex organs like the heart, liver and kidney.

3: biological pumps based on the cardioid model. (a) Cardioid formation—Cardioids are formed by the spontaneous delamination of a cohesive monolayer of primary cardiac cells on the surface of a carefully controlled cell culture surface. (b) Formation of biological pumps—a tubular graft is positioned at the center of the delaminating cell monolayer. Delamination of the cell monolayer results in the formation of a cell layer on the outer surface of the tubular graft. This process results in the formation of biological pumps .

The catheter was submerged in the cell–gel suspension and gel compaction resulted in formation of a cell layer around the outer surface of the catheter. The process results in the fabrication of cardiac organoids, which were shown to generate intra-luminal pressures in the range of 1–2 mmHg . . 214 xxxii List of Figures Fig. 11 Fig. 12 Fig. 13 Fig. 14 Fig. 15 Case study 7–2: fabrication of bioartificial ventricles. (a) Normal heart and HLHS heart. (b) Overview of closed system-adding the tricuspid valve to the scaffold .

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