Applied Mathematicsematics

Obsessive Compulsive Disorder. Current Understanding and by Y C Janardhan Reddy, Shoba Srinath

By Y C Janardhan Reddy, Shoba Srinath

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Extra resources for Obsessive Compulsive Disorder. Current Understanding and Future Directions

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This consists of a series of parallel segregated frontal-subcortical projecting back to the circuit's origin in areas 9 and 10 of the dorsolateral circuits now known to link specific regions of the frontal cortex to the frontal lobe. The mediodorsal thalamus closes the circuit by striatum, the globus pallidus and substantia nigra, and the thalamus, constituting an important effector mechanism that allows the organism to interact adaptively with its environment. The lateral division of the orbitofrontal circuit originates in the lateral orbital gyrus of Brodmann's area 11 and the medial inferior frontal gyrus of the areas 10 and 47 in humans.

Approach for the treatment of disorders, such as major depression and OCD, currently treated with antidepressants (111). Positron Emission Tomography studies have shown an increased metabolic activity in brain circuit involving the involving the orbitofrontal cortex (OFC), Glutamate the head of the caudate nucleus, and the thalamus (108, 109). A successful According to Carlsson (112), OCD is considered to be a treatment (pharmacological or behavioural) is associated with a normalization hyperglutamatergic state involving prefrontal brain regions.

Emotional deficits. The former is coordinated primarily by the dorsolateral prefrontal cortex and the latter by the ventral prefrontal cortex. Both these Such decision-making impairments also suggest executive dysfunction in OCD. brain regions (and the functions sub-served by them as well) are influenced by Indeed, a recent comprehensive review suggests that executive interactions with the anterior cingulate cortex. Such a view, though simplistic, dysfunction could be a major neuropsychological deficit in OCD.

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