By Valerie Askanas, W. King Engel
The getting older of society is resulting in many demanding situations throughout all parts of medication. the issues of muscle getting older have ended in an increase within the prevalence of much less universal stipulations, which although now not terminal are debilitating and often revolutionary, and infrequently underdiagnosed or misdiagnosed. Written by means of a crew of foreign specialists, this landmark e-book will examine the final medical difficulties linked to muscle getting older ahead of interpreting inclusion-body myositis and myopathies, a gaggle of the extra vital illnesses of muscle getting older. With case vignettes to assist analysis to make sure right administration of an disorder, this is a vital reference for pros and scholars.
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Extra resources for Muscle Aging, Inclusion-Body Myositis and Myopathies
2010) Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. Biochem Biophys Res Commun 391, 1548–1554. Gustafsson T, Osterlund T, Flanagan JN et al. (2010) Effects of 3 days unloading on molecular regulators of muscle size in humans. J Appl Physiol 109, 721–727. Murphy KT, Cobani V, Ryall JG et al. (2011) Acute antibody-directed myostatin inhibition attenuates disuse muscle atrophy and weakness in mice. J Appl Physiol 110, 1065–1072. Castillero E, Nieto-Bona MP, Fernandez-Galaz C et al.
Perhaps in the patients the autoimmune attack is on the tendons. Vascular aspects of aging muscle These are discussed in Chapter 2 of this volume. Putative animal “models” of human “AAM”: biochemical studies Such studies are numerous. They will not be reviewed in detail, partly because it is not certain which are directly relevant to the complex human problem. Because therapy for patients is the ultimate goal, biochemical studies of aging human muscle would be relevant to understanding the pathogenesis of aging atrophy if, in the patients studied, the disorder is actually primary within their muscle ﬁbers.
50 Jespersen JG, Nedergaard A, Andersen LL et al. (2011) Myostatin expression during human muscle hypertrophy and subsequent atrophy: increased myostatin with detraining. Scand J Med Sci Sports 21, 215–223. 51 Kamanga-Sollo E, Pampusch MS, White ME et al. (2003) Role of insulin-like growth factor binding protein (IGFBP)-3 in TGF-beta- and GDF-8 (myostatin)-induced suppression of proliferation in 30 52 53 54 55 56 57 58 59 60 61 62 Muscle Aging porcine embryonic myogenic cell cultures. J Cell Physiol 197, 225–231.