Physiology

Molecular Mechanisms of Exocytosis by Romano Regazzi Ph.D. (auth.)

By Romano Regazzi Ph.D. (auth.)

Exocytosis is a primary mobile strategy that's utilized by eukaryotic cells to unlock numerous organic compounds together with peptide hormones and neurotransmitters or to insert particular lipids and proteins within the plasma membrane. lately, a multidisciplinary strategy promoted a unprecedented development within the realizing of the molecular mechanisms regulating exocytosis. This resulted in the invention of a giant variety of elements belonging to the equipment that governs the fusion of secretory vesicles with plasma membranes in numerous cellphone structures, together with neuronal and endocrine cells. the elemental equipment required for vesicle fusion grew to become out to be good conserved via evolution from yeast to guy. to this point, as a result of the huge variety of elements concerned, figuring out of the molecular foundation of exocytosis has remained the privilege of a comparatively small crew of experts. This ebook, written via well-known specialists within the box goals at clarifying for a non-specialist viewers the function of the main gamers within the exocytotic technique not just in neuronal and endocrine cells but additionally in a number of different correct cellphone platforms. The booklet represents a distinct selection of updated experiences that may introduce researchers and scholars to the vanguard of this swiftly relocating and interesting box.

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Despite the absence of C2 domains multiple interactions between Slac2 and other cellular components, in particular with cytoskeletal elements, have been reported. ^ Later on mutations of Rab27A and Myosin Va genes were reported to lead to a similar phenotype, suggesting a functional relationship between Melanophilin and these two proteins. Indeed, a number of results obtained in melanocyte cultures demonstrate that these three proteins form a functional complex that is essential for melanosome transport.

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Wing MR, Bourdon D M , Harden TK. PLC-epsilon: A shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling. Mol Interv 2003; 3:273-280. Regulation of SNARE Complex Assembly by Second Messengers 23 36. Balsinde J, Winstead MV, Dennis EA. Phospholipase A(2) regulation of arachidonic acid mobilization. FEES Lett 2002; 531:2-6. 37. Brown WJ, Chambers K, Doody A. Phospholipase A2 (PLA2) enzymes in membrane trafficking: Mediators of membrane shape and function. Traffic 2003; 4:214-221.

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