By Johnathan D. Kibble, Colby R. Halsey
Get the massive photograph of scientific body structure -- and concentrate on what you actually need to grasp to ace the path and board exams!
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• insurance of the entire crucial parts of body structure, together with basic, Neurophysiology, Blood, Cardiovascular, Pulmonary, Renal and Acid Base, Gastrointestinal, and Reproductive
• 450 classified and defined full-color illustrations
• one hundred ninety board exam-style questions and solutions -- together with a whole perform try on the finish of the book
• detailed icon highlights very important medical details
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Additional info for Medical Physiology: The Big Picture (LANGE The Big Picture)
Hormones or neurotransmitters Depolarization Opens voltage-gated Ca2+ channels IP3 Hormones or neurotransmitters Ca2+ release from SR Open ligand-gated Ca2+ channels [Ca2+] Ca2+-calmodulin (CaM) myosin-light-chain kinase Phosphorylation of myosin light chains Myosin ATPase Myosin~P + actin Cross-bridge cycling FIGURE 1-16 Sequence of events in contraction of smooth muscle. Tension 98761_Ch01 5/7/10 6:38 PM Page 22 22 Board Review Series: Physiology ■ There is no troponin; instead, Ca2+ regulates myosin on the thick filaments.
B. Muscarinic receptors ■ ■ ■ ■ ■ ■ are located in the heart (M2 ), smooth muscle (M3 ), and glands (M3 ). , decreased heart rate, decreased conduction velocity in AV node). , increased GI motility, increased secretion). are activated by ACh and muscarine. are blocked by atropine. Mechanism of action: (1) Heart SA node: Gi protein, inhibition of adenylate cyclase, which leads to opening of K+ channels, slowing of the rate of spontaneous Phase 4 depolarization, and decreased heart rate. (2) Smooth muscle and glands: Gq protein, stimulation of phospholipase C, and increase in IP3 and intracellular [Ca2+].
Receptor types in the ANS (Table 2-2) 1. Adrenergic receptors (adrenoreceptors) a. `1 Receptors ■ ■ ■ ■ are located on vascular smooth muscle of the skin and splanchnic regions, the gastrointestinal (GI) and bladder sphincters, and the radial muscle of the iris. , contraction or constriction). are equally sensitive to norepinephrine and epinephrine. However, only norepinephrine released from adrenergic neurons is present in high enough concentrations to activate α1 receptors. Mechanism of action: Gq protein, stimulation of phospholipase C, and increase in inositol 1,4,5-triphosphate (IP3) and intracellular [Ca2+].