Physiology

Mathematical Physiology: II: Systems Physiology by James Keener, James Sneyd

By James Keener, James Sneyd

There has been a protracted heritage of interplay among arithmetic and body structure. This e-book seems intimately at a big variety of mathematical types in body structure, exhibiting how physiological difficulties should be formulated and studied mathematically, and the way such types provide upward thrust to fascinating and difficult mathematical questions. With its assurance of many fresh versions it supplies an summary of the sphere, whereas many older versions also are mentioned, to place the fashionable paintings in context.

In this moment version the insurance of easy ideas has been extended to incorporate such themes as stochastic differential equations, Markov types and Gibbs loose strength, and the choice of versions has additionally been extended to incorporate a number of the easy versions of fluid delivery, respiration/perfusion, blood ailments, molecular vehicles, gentle muscle, neuroendrocine cells, the baroreceptor loop, turboglomerular oscillations, blood clotting and the retina.

Owing to this large assurance, the second one version is released in volumes. This moment quantity offers with the body structure of structures and the 1st quantity with the elemental rules of mobile physiology.

The publication comprises particular illustrations and diverse excercises with chosen recommendations. The emphasis all through is at the functions; due to this interdisciplinary process, this publication may be of curiosity to scholars and researchers, not just in arithmetic, but in addition in bioengineering, physics, chemistry, biology, data and medicine.

James Keener is a distinctive Professor of arithmetic on the collage of Utah. He and his spouse dwell in Salt Lake urban, yet do not be shocked if he strikes to the mountains.


James Sneyd is the Professor of utilized arithmetic on the collage of Auckland in New Zealand, the place he has labored for the prior six years. He lives along with his spouse and 3 childrens beside a seashore, and may otherwise be swimming.

Reviews of the 1st edition:

...probably the easiest publication ever written at the interdisciplinary box of mathematical body structure. Mathematical experiences, 2000

In addition to being solid analyzing, first-class pedagogy, and attractive technology, the exposition is lucid and transparent, and there are various strong challenge units to settle on from... hugely steered. Mathematical Biosciences, 1999

Both authors are professional specialists within the box of mathematical body structure and especially within the box of excitability, calcium dynamics and spiral waves. It directs scholars to develop into no longer basically expert technicians in organic learn yet masters of the technological know-how. SIAM, 2004

The first variation used to be the winner of the 1998 organization of yankee Publishers "Best New identify in Mathematics."

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Extra resources for Mathematical Physiology: II: Systems Physiology

Example text

However, much can be learned using linear approximations to the governing equations. The simplest linear model is due to Guyton (1963), in which the circulatory system is represented as a closed loop with two compliance vessels and one pure resistance vessel (Fig. 7). The large arteries and veins are each treated as compliance vessels with linearized flow equations, and the systemic capillaries are treated as a resistance vessel with no compliance. The equations describing this model can be conveniently divided into two groups: those describing the arterial system and those describing the venous system.

Clearly, the higher the compliance, the smaller the pressure drop required to drive a given fluid flux. This explains, for example, why the pressure drop in the veins can be much less than in the arteries, since the compliance of the veins is much greater than the compliance of the arteries. We also calculate the volume of blood contained in a vessel with input pressure P0 and output pressure P1 to be V= L 0 A(x) dx = P1 P0 A(P)x (P) dP = − 1 8π μQ P1 P0 A3 (P) dP. 3 Scaled flow RQ (with units of pressure) as a function of pressure drop P = P0 − P1 for different values of compliance γ .

One other parameter that has an important effect is the diastolic compliance of the left heart, Cld . As expected, if this compliance decreases, there is a reduction in systemic arterial pressure and a reduction in cardiac output. There is also a noticeable increase in pulmonary blood volume, Vp . Thus, left heart failure, which corresponds to a weakening of the left ventricular muscles and hence decreased cardiac efficiency and decreased compliance, results in excess fluid and fluid congestion in the lungs, known as pulmonary edema.

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