Physiology

Marks' Basic Medical Biochemistry: A Clinical Approach by Colleen Smith PhD, Allan Marks MD, Michael Lieberman PhD

By Colleen Smith PhD, Allan Marks MD, Michael Lieberman PhD

Offers a different clinically established strategy that's excellent for scientific scholars. sufferer vignettes during the booklet emphasize the significance of biochemistry to medication.

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44) and that ketone bodies are present in both blood and urine. Her blood glucose level is 648 mg/dL (reference range ϭ 80Ϫ110 after an overnight fast, and no higher than 200 in a casual glucose sample taken without regard to the time of a last meal). I. A. Total body water WAITING ECF = 15 L 5 L Blood Fig. 2. Fluid compartments in the body based on an average 70-kg man. Total body water is roughly 50 to 60% of body weight in adults and 75% of body weight in children. Because fat has relatively little water associated with it, obese people tend to have a lower percentage of body water than thin people, women tend to have a lower percentage than men, and older people have a lower percentage than younger people.

Muscle uses fatty acids, ketone bodies, and (when exercising and while supplies last) glucose from muscle glycogen. Many other tissues use either fatty acids or ketone bodies. However, red blood cells, the brain, and other neural tissues use mainly glucose. 1. II. METABOLIC CHANGES DURING PROLONGED FASTING If the pattern of fuel utilization that occurs during a brief fast were to persist for an extended period, the body’s protein would be quite rapidly consumed to the point at which critical functions would be compromised.

Dissociation of water. 3. The ion product of water. 4. The K acid For the reaction HA 4 AϪ ϩ Hϩ Ka ϭ [H ϩ ] [A Ϫ ] [HA] B. 2). These metabolically important acids can be classified as weak acids or strong acids by their degree of dissociation into a hydrogen ion and a base (the anion component). Inorganic acids such as sulfuric acid (H2SO4) and hydrochloric acid (HCl) are strong acids that dissociate completely in solution (Fig. 6). , the ketone bodies acetoacetic acid and ␤-hydroxybutyric acid) are weak acids that dissociate only to a limited extent in water.

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