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Hydrophillic Interaction Liquid Chromatography (Hilic) and by Perry G. Wang, Weixuan He

By Perry G. Wang, Weixuan He

This is often the 1st e-book that comprehensively and systematically describes the recent know-how of hydrophilic interplay liquid chromatography (HILIC). Hydrophilic interplay chromatography is a separation process appropriate for polar and hydrophilic compounds and orthogonal to reversed section liquid chromatography. From small natural molecules to proteins, the textual content explores the various functions of HILIC within the analytical box. Winner of the President's Award for Excellence, the writer explains how HILIC can considerably increase analytical throughput through shortening pattern practise strategy, that is one of many bottlenecks for drug discovery and improvement within the pharmaceutical undefined.

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Anal. , 2001, 293, 129. 6. , J. Chromatogr. B, 2007, 860, 57. 7. Dorion, S. , Anal. , 2003, 323, 188. 8. , Anal. , 2003, 75, 2349. 9. , Anal. , 2007, 79, 6573. 10.  Chromatogr. A, 2006, 1125, 76. 11. , Anal. , 2007, 363, 185. 12. , Rapid Commun. , 2005, 19, 3031. 13. , Rapid Commun. , 2003, 17, 2549. 14. , Anal. , 2007, 7, 8911. 15. J. , J. Liq. Chromatogr. Relat. , 2006, 29, 1105. 16. , Rapid Commun. , 2002, 16, 1965. 17. , Rapid Commun. , 2007, 21, 3145. 18. , J. Chromatogr. A, 2007, 1172, 19.

4. 21 A series of cytidine-related compounds were tested for their ANP retention on a hydride-based stationary phase. Unsubstituted cytidine is sufficiently polar so that it can be easily retained with high amounts of organic in the mobile phase and an additive such as formic or acetic acid. As hydrophobic substituents are added to the molecule, a more nonpolar moiety is created and these molecules have RP retention. 18 for three substituted cytidines that have alkyl side chains of varying length.

The high level of orthogonality and the unique selectivity of HILIC relative to reversed-phase chromatography may also provide the means of separating isobaric compounds and other interferences that cannot be achieved by reversed-phase chromatography. This alternative selectivity is very advantageous during the early stages of drug candidate development when in vivo metabolic transformation knowledge is limited. 1–4 Bioanalysis plays an important role in drug development, in which the speed of method development is a critical factor.

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