By Robert O. Williams III, Alan B. Watts, Dave A. Miller
The target of this quantity is to consolidate inside a unmarried textual content the most up-tp-date wisdom, functional equipment, and regulatory concerns bearing on formulations improvement with poorly water-soluble molecules. A pharmaceutical scientist’s strategy towards solubility enhancement of a poorly water-soluble molecule mostly contains targeted characterization of the compound’s physiochemical houses, solid-state alterations, complicated formula layout, non-conventional procedure applied sciences, complex analytical characterization, and really expert product functionality research concepts. The scientist also needs to pay attention to the original regulatory concerns touching on the non-conventional techniques usually applied for poorly water-soluble medications. One confronted with the problem of constructing a drug product from a poorly soluble compound needs to own at minimal a operating wisdom of every of the abovementioned features and certain wisdom of such a lot. In gentle of the significance of the turning out to be solubility challenge to drug improvement, this can be a major burden particularly while due to the fact wisdom in almost all these parts is comparatively new and keeps to develop
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Additional resources for Formulating Poorly Water Soluble Drugs
Lippincott Williams & Wilkins, Baltimore Alqawlaq S, Huzil JT, Ivanova MV, Foldvari M (2012) Challenges in neuroprotective nanomedicine development: progress towards noninvasive gene therapy of glaucoma. Nanomedicine 7(7):1067–1083 Amidon GL, Lennernäs H, Shah VP, Crison JR (1995) A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 12(3):413–420 Amin K, Dannenfelser RM (2006) In vitro hemolysis: guidance for the pharmaceutical scientist.
AIChE J 44(1):214–225 Egger-Heigold B (2005) The effect of excipients on pharmacokinetic parameters of parenteral drugs. PhD Thesis, Faculty of Science, University of Basel El-Gendy N, Selvam P, Soni P, Berkland C (2012a) Development of budesonide nanocluster dry powder aerosols: processing. J Pharm Sci 101(9):3425–3433 El-Gendy N, Huang S, Selvam P, Soni P, Berkland C (2012b) Development of budesonide nanocluster dry powder aerosols: formulation and stability. J Pharm Sci 101(9):3445–3455 Ellis AG, Crinis NA, Webster LK (1996) Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80.
PhD Thesis, Faculty of Science, University of Basel El-Gendy N, Selvam P, Soni P, Berkland C (2012a) Development of budesonide nanocluster dry powder aerosols: processing. J Pharm Sci 101(9):3425–3433 El-Gendy N, Huang S, Selvam P, Soni P, Berkland C (2012b) Development of budesonide nanocluster dry powder aerosols: formulation and stability. J Pharm Sci 101(9):3445–3455 Ellis AG, Crinis NA, Webster LK (1996) Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80.