Physiology

Dynamic Plasma Membranes: Portals Between Cells and by Vann Bennett

By Vann Bennett

This quantity focuses on the recent advances in knowing plasma membrane association and serve as starting with basic platforms and increasing to really good membrane domain names of vertebrate cells.

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This is a classical liquidevapor phase transition. This phenomenon of two-dimensional phase separation has very recently been demonstrated/ observed on reconstituted supported cell membranes (Banjade & Rosen, 2014), where large domains of Nephrin, Nck, and N-WASP proteins were observed to form above a critical concentration, without the necessity of lipid segregation. ” Note, however, that in this work the system is not asserted to be at equilibrium (reaching equilibrium through domain coarsening can be a very long process (Bray, 1994)), thus the large micrometric clusters are likely to coalesce further and to produce “giant” phases.

Conclusion References ́ 57 58 ́ Abstract For several decades, the phenomenon of membrane component segregation into microdomains has been a well-known and highly debated subject, and varying concepts including the raft hypothesis, the fence-and-picket model, hydrophobicmismatch, and specific proteineprotein interactions have been offered as explanations. Here, we review the level of insight into the molecular architecture of membrane domains one is capable of obtaining through biological experimentation.

2013). Discussed clustering mechanisms involve the TMS (5) via mechanisms involving cholesterol or hydrophobic mismatch (see text). , 2006, 2007). A Converging View on Membrane Microdomain Dynamics 33 SNAREs also have an autonomously folded N-terminal domain attached via a linker region to the SNARE-motif (Figure 2). Different types of SNAREs, occupying opposed membranes, can form complexes via their SNARE-motifs, thereby mediating membrane fusion. Such heterooligomeric SNARE complexes are formed from four SNARE-motifs provided from three to four different SNAREs (please note that a few SNAREs have two SNARE-motifs).

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