By Geoffrey H. Bourne
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Even in precedent days, respiring used to be believed to be crucial characteristic of lifestyles itself. The very Universe used to be considered as an enormous respiring organism, during which every little thing used to be concerning every little thing else via a means of vibration - or breath. these days, our knowing of the legislation governing the Universe and existence has complicated significantly.
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Extra resources for Calcification and Physiology
Clearly, the volume of the collagen fibrillar component will be equal to the sum of ( 1 ) and ( 2 ) . Katz and Li submit equations by which the volumes occupied in these ways (expressed as a ratio of total tissue volume) are related to various other quantities, which can be measured experimentally. Katz and Li (1973) devised two experimental techniques to determine Vi7 the volume occupied by solid collagen. By one method they measured the volume of intrafibrillar water which is not accessible to labeled polyethylene glycol and calculated by the value of Vi.
2,3-Diphosphoglycerate, as well as pyrophosphate, present in physiological compartments in sufficient quantities, may influence the rate of biological calcification. Both intra- and extracellular fluid compartments may contain inhibitors that function either in the intracellular organelles or in extracellular sites. The magnesium-sensitive phosphate-independent binding of calcium or strontium by the catalytic matrix (Wadkins et al, 1974) is consistent with the postulates of Waddell ( 1972 ) and the theory of triphasic mechanism of calcification proposed by Urist et al.
Fleisch et al (1973), and Russell et al. (1973). In toxic doses, some biological substances are as unphysiological as nonbiological inhibitors and may either inhibit transfer of calcium across membranes or block crystal growth. Cuervo and associates (1971) demonstrated that aggregate forms of proteoglycan possess a potent inhibitory effect on growth in vitro. Nonaggregate forms are noninhibitory in concentrations found in micropuncture fluids but become inhibitory when assembled into aggregate areas.