Physiology

BCL2 Protein Family: Essential Regulators of Cell Death by Claudio Hetz

By Claudio Hetz

During this publication, scientists pioneering the sector have compiled a chain of concentrated chapters to focus on the relevance of the BCL‑2 family members of proteins in apoptosis, body structure and illness. a tremendous concentration of this quantity is thinking about the capability TH period PEUT IC merits of concentrating on apoptosis pathways within the context of human ailment. Readers attracted to figuring out how a telephone handles tension and the results of dysregulation of this approach for human sickness will locate this booklet very priceless. It makes an attempt to explain a desirable sector of study the place body structure and biomedicine converge at various degrees, revealing a visit from the molecular legislation of apoptosis to the influence of this technique to the body structure of an entire organism.

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BCL2 Protein Family: Essential Regulators of Cell Death

During this e-book, scientists pioneering the sphere have compiled a chain of targeted chapters to focus on the relevance of the BCL‑2 relations of proteins in apoptosis, body structure and sickness. a huge concentration of this quantity is thinking about the aptitude TH period PEUT IC merits of concentrating on apoptosis pathways within the context of human illness.

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Neuspiel M, Zunino R, Gangaraju S et al. Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation and reduces susceptibility to radical induced depolarization. J Biol Chem 2005; 280(26):25060-25070. 107. Wasiak S, Zunino R, McBride HM. Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J Cell Biol 2007; 177(3):439-450. 108. Niemann A, Ruegg M, La Padula V et al. Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease.

EMBO 1998; 17(17):4987-5000. 75. Territo PR, Mootha VK, French SA et al. Ca(2 ) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase. Am J Physiol Cell Physiol 2000; 278(2):C423-435. 76. Jouaville LS, Pinton P, Bastianutto C et al. Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc Natl Acad Sci USA 1999; 96(24):13807-13812. 77. Szalai G, Krishnamurthy R, Hajnoczky G. Apoptosis driven by IP(3)-linked mitochondrial calcium signals.

52. Pinton P, Ferrari D, Rapizzi E et al. The Ca2 concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of BCL-2 action. EMBO J 2001; 20(11):2690-2701. 53. Wang NS, Unkila MT, Reineks EZ et al. Transient expression of wild-type or mitochondrially targeted BCL-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted BCL-2 is protective against Bax-induced cell death. J Biol Chem 2001; 276(47):44117-44128.

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