Advances in Tracer Methodology: Volume 2 A collection of by Martin D. Kamen (auth.), Seymour Rothchild (eds.)

By Martin D. Kamen (auth.), Seymour Rothchild (eds.)

Advances in Tracer method, quantity 2, files the professional­ ceedings of the sixth, seventh, and eighth Symposia on Advances in Tracer technique. those Symposia, that are a part of a continual sequence subsidized by means of the recent England Nuclear Corp. and the Packard tool corporation, Inc., are dedicated to the whole isotope tracer box: instruction and research of categorized compounds, purposes within the chemical, biochemical, and scientific fields, and overall healthiness physics issues linked to tracer paintings. The papers during this quantity mirror definite tendencies which might be famous within the tracer box: expanding reliance on biochemical tools for labeling esoteric compounds, starting to be know-how of the issues of radiation decomposition, using complex instrumentation for the research and detection of radioactive substrates, and the swiftly transforming into software of tracer compounds to medical analysis. the 3 Symposia at which the papers have been offered have been hung on the next dates: DATE position CHAIRMAN 11/16/62 manhattan urban Daniel Steinberg, leader Laboratory of Ce1lular body structure and Metabolism, nationwide middle Institute, Bethesda, Maryland 3/8/63 l. a. Martin Kamen college of California San Diego, California 11/8/63 Chicago Joseph L. Rabinowitz Veterans management medical institution Philadelphia, Pennsylvania once more, it's the editor's excitement to recognize the aid of his colleagues in making plans and operating many of the Symposia, in addition to the superb cooperation of the chairmen, who acquitted themselves of their appointed projects in a best demeanour, With humor and realizing. S. R. Boston, Mass.

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Kindel. P. K .. and Gibbs. 1. BioI. Chern. 236:2850 (1961) Ljungdahl. L .. Wood. G .. Racker. • J. BioI. Chern. 236:1622 (1961). Spencer. F .. and Lowenstein. • J. BioI. Chern. 237:3640 (1962). Bhaduri. A•• and Srere, P. A.. Biochirn. Biophys. Acta 70:221 (1963). Varner. J. E .. in: Methods in Enzymology. Vol. III (S. P. Colowick and N. O. ). Academic Press. New York (1957). p. 397. 8. Rose. I. • Kellermeyer, R .. Stjernholrn. R.. and Wood. H. G .. J. Bioi. Chern. 237:3325 (1962). S. Abraham 59 9.

20 I ~ p I 10 ~ / 0 I \ - Calculated - - Observed \ ~ \ \ b \ 0 16 Fig. 5 and several hours of reaction. The apparent activation energy of the system D20/n-C 5 is 42 kcal/mole, which is considerably higher than the values of ~ 15 kcal/mole reported for Ddalkanes, suggesting that water may act as a catalyst pOison. Exchange with D2 gas is not only considerably faster than with D20 but results in less decomposition of the labeled material (5-10'% decomposition for D 20/n-C 5 and <1,% for D2/n-:-C 5).

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